Lhassane Ismaili Selected Research

Cholinesterases (Cholinesterase)

1/2021	(±)-BIGI-3h: Pentatarget-Directed Ligand combining Cholinesterase, Monoamine Oxidase, and Glycogen Synthase Kinase 3β Inhibition with Calcium Channel Antagonism and Antiaggregating Properties for Alzheimer's Disease.
5/2020	Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
1/2020	Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy.
12/2019	New Dual Small Molecules for Alzheimer's Disease Therapy Combining Histamine H3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition.
7/2018	Tacripyrimidines, the first tacrine-dihydropyrimidine hybrids, as multi-target-directed ligands for Alzheimer's disease.
10/2017	Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
11/2016	The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
6/2016	Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aβ1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.

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Lhassane Ismaili Research Topics

Disease

25	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 01/2016
3	Cognitive Dysfunction 01/2020 - 01/2016
3	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2017 - 01/2017
1	Neoplasms (Cancer) 11/2021
1	Breast Neoplasms (Breast Cancer) 11/2021
1	Chronic Disease (Chronic Diseases) 10/2021
1	Amyloid Plaque 01/2019
1	Brain Ischemia (Cerebral Ischemia) 01/2011
1	Neuroblastoma 01/2011

Drug/Important Bio-Agent (IBA)

13	AntioxidantsIBA 10/2020 - 01/2011
11	Biological ProductsIBA 11/2021 - 05/2016
8	Cholinesterases (Cholinesterase)IBA 01/2021 - 06/2016
7	LigandsIBA 01/2022 - 01/2016
4	Tacrine (Cognex)FDA Link 01/2021 - 11/2016
4	Calcium Channels (Calcium Channel)IBA 01/2021 - 07/2018
4	Monoamine Oxidase (MAO)IBA 01/2021 - 01/2016
4	Cholinesterase Inhibitors (Anticholinesterases)IBA 01/2017 - 03/2016
3	Cholinergic Agents (Cholinergics)IBA 01/2019 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 11/2021 - 01/2020
2	Dihydrotachysterol (AT 10)IBA 10/2020 - 03/2020
2	Amyloid beta-PeptidesIBA 07/2020 - 01/2017
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2020 - 01/2017
2	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 01/2017
2	propargylamineIBA 01/2020 - 01/2016
2	Amyloid (Amyloid Fibrils)IBA 01/2017 - 01/2016
2	Donepezil (Aricept)FDA LinkGeneric 01/2017 - 01/2016
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 11/2021
1	Glycogen Synthase KinasesIBA 01/2021
1	1,4-dihydropyridine (dihydropyridine)IBA 10/2020
1	Choline O-Acetyltransferase (Choline Acetyltransferase)IBA 07/2020
1	Peptides (Polypeptides)IBA 07/2020
1	AcetylcholinesteraseIBA 05/2020
1	QuinolonesIBA 05/2020
1	pyridineIBA 03/2020
1	Mitochondrial Permeability Transition PoreIBA 01/2020
1	MetalsIBA 01/2020
1	IronIBA 01/2020
1	Protein Kinase CIBA 01/2020
1	LipopolysaccharidesIBA 12/2019
1	Histamine H3 Receptors (Histamine H3 Receptor)IBA 12/2019
1	6- hydroxy- 2,5,7,8- tetramethylchroman- 2- carboxylic acid (Trolox)IBA 10/2019
1	Histamine (Histamine Dihydrochloride)FDA Link 10/2017
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2017
1	Serotonin ReceptorsIBA 01/2017
1	Thioctic Acid (Lipoic Acid)IBA 11/2016
1	Cyanides (Isocyanides)IBA 11/2016
1	Formaldehyde (Formol)FDA Link 11/2016
1	MelatoninIBA 11/2016
1	Scopolamine (Hyoscine)FDA Link 01/2016
1	N- ((5- (3- (1- benzylpiperidin- 4- yl)propoxy)- 1- methyl- 1H- indol- 2- yl)methyl)- N- methylprop- 2- yn- 1- amineIBA 01/2016
1	N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamineIBA 01/2016
1	oligomycin AIBA 01/2011
1	nitronesIBA 01/2011
1	RotenoneIBA 01/2011

Therapy/Procedure

17	Therapeutics 10/2021 - 01/2016
1	Drug Therapy (Chemotherapy) 11/2021